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Alam Laboratory

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Current Projects

    

Steroid resistance of airway ILC2s

Major Goals: The major goals are to: 1: Study the mechanism of TSLP-induced steroid resistance of human ILC2s, 2: Establish the biological relevance of TSLP-induced steroid resistance in a mouse model of chronic asthma and evaluate therapeutic interventions in vivo.  3: Study steroid resistance of airway ILC2s and T cells from asthmatic patients and assess therapeutic interventions in vitro.

Project Number: 5 R01 AI 137970-04
Name of PD/PI: Alam, R.
Source of Support: NIH/NIAID
Primary Place of Performance: National Jewish Health, Denver
Project/Proposal Start and End Date: 05/15/2018 - 04/30/2023
Total Award Amount (including Indirect Costs): $2,305,458


   

ILC2 memory in asthma

Major Goals: The major goals are to 1: To study the induction of memory-driven asthma and memory ILCs by PAMPs 2: To elucidate the mechanism of formation of ILC memory; and 3: To examine the relevance of memory ILC2s for eosinophilic non-allergic asthma. 

Project Number: 1 R01 AI 157138-01
Name of PD/PI: Alam, R.
Source of Support: NIH/NIAID
Primary Place of Performance: National Jewish Health, Denver
Project/Proposal Start and End Date:: 09/21/2020 - 08/31/2025
* Total Award Amount (including Indirect Costs): $3,059,940


   

DNA induction of neutrophilic asthma  

Major Goals: The major goals are to 1: To examine the relevance of extracellular DNA for human neutrophilic asthma, and 2: To study the mechanism of extracellular DNA-induced neutrophilic asthma in mice.

Project Number: 1 R01 AI 165922-01
Name of PD/PI: Alam, R.
Source of Support: NIH/NIAID
Primary Place of Performance: National Jewish Health, Denver
Project/Proposal Start and End Date:: 12/01/2021 - 011/30/2026
Total Award Amount (including Indirect Costs): $2,455,981