Resources & Services
Dr. Brian Day’s laboratory is located on the 4th floor of the Smith building on National Jewish Health’s campus.
Research Methods
Quantitating Oxidants
- Superoxide
- Hydrogen Peroxide
- Hypohalous Acids
Quantitating markers of oxidative stress
- Lipid oxidation
- 4HNE by GC/MS
- F2 isoprostane by GC/MS
- 7-OH-cholesterol by GC/MS
- Protein oxidation
- Nitro tyrosine by HPLC-EC
- Chloro-tyrosine by HPLC-EC
- Protein- GSH by HPLC-EC
- GSH/GSSG
- Spectrophotometric
- HPLC-FD
- HPLC-EC
- DNA oxidation
- 8-OH-2dG by HPLC-EC
Pharmacokinetics of drugs and biomarkers (non-GLP)
- HPLC
Pharmaceutical Formulations and Delivery Systems
- Extended release sub cutaneous injection
- Inhalation delivery systems
Therapeutic Safety Assessments (non-GLP)
- Ames Assay
- Maximum Tolerated Dose
- NOEL
- Therapeutic Index
Animal Models
- SOD1 KO
- SOD2 KO
- CFTR KO
- GCLM KO
- bENaC Tg
Human CF Bacterial Isolates
- Pseudomonas aeruginosa
- Burkholderia cepacia complex
- Staphylococcus aureus
- Mycobacterium abscesses
Patents
- Oxidant Scavengers, US #5,994,339 (1999)
- Oxidant Scavengers, US #6,127,356 (2000)
- Paraquat, Dipyridinium-Based Inhibitors of Nitric Oxide Synthase, Related Compounds & Therapeutic Uses Thereof, US #6,231,894 (2001); Australian #778,967
- Substituted Porphyrins, US #6,479,477 (2002)
- Substituted Porphyrins, US #6,544,975 (2003)
- Oxidant Scavengers, US #6,583,132 (2003)
- Methods for Identifying Compounds as Antioxidants, US #6,900,026 (2005)
- Substituted Porphyrins, US #6,916,799 (2005)
- Substituted Porphyrins, US #7,189,707 (2007)
- Oxidant Scavengers, US #7,470,677 (2008)
- Methods for treatment of thiol-containing compound deficient conditions, US #7,498,047 (2009)
- Compounds and methods for thiol-containing compound efflux and cancer treatment, US#7,790,762 (2010)
- Substituted Porphyrins, US#7,820,644 (2010)
- Substituted Porphyrins, US#8,217,026 (2012)
- Oxidant scavengers for treatment of type I or type II diabetes, US#8,470,808 (2013)
- Substituted Porphyrins, US#8,546,562 (2013)
- Cancer Therapy, US#8,765,729 (2014)
- Substituted Porphyrins, US#8,946,202 (2015)
- Substituted Porphyrins, US#9,289,434 (2016)
- Methods and compositions for treating infection and inflammation with selenocyanate, US #10,751,315 (2020)