Recent Publications
Lee FFY, Harris C, Alper S. RNA Binding Proteins that Mediate LPS-induced Alternative Splicing of the MyD88 Innate Immune Regulator. J Mol Biol. 2024 Feb 17;436(8):168497.
Gurule NJ, Malcolm KC, Harris C, Knapp JR, O'Connor BP, McClendon J, Janssen WJ, Lee FFY, Price C, Osaghae-Nosa J, Wheeler EA, McMahon CM, Pietras EM, Pollyea DA, Alper S. Myelodysplastic neoplasm-associated U2AF1 mutations induce host defense defects by compromising neutrophil chemotaxis. Leukemia. 2023 Oct;37(10):2115-2124.
Lee FFY and Alper S. Alternative pre-mRNA splicing as a mechanism for terminating Toll-like Receptor signaling. Front Immunol. 13:1023567 (2022).
Saleh LS, Amer LD, Thompson B, Danhorn T, Knapp JR, Gibbings SL, Thomas S, Barthel L, O’Connor BP, Janssen W, Alper S, and Bryant ST. Mapping macrophage polarization and origin during the progression of the foreign body response to a poly(ethylene glycol) hydrogel implant. Adv Healthc Mater. 11(9):e2102209 (2022).
Pollyea DA, Kim HM, Stevens BM, Lee FFY, Harris C, Hedin BR, Knapp JR, O’Connor BP, Jordan CT, Pietras EM, Tan AC, and Alper S. MDS-associated SF3B1 mutations enhance proinflammatory gene expression in patient blast cells. J. Leukoc Biol. 110(1):197-205 (2021).
Lee FFY, Davidson K, Harris C, McClendon J, Janssen WJ, and Alper S. NF-kappaB mediates lipopolysaccharide-induced alternative pre-mRNA splicing of MyD88 in mouse macrophages. J. Biol. Chem. 295(18):6236-6248. (2020).
Janssen WJ, Danhorn T, Harris C, Mould KJ, Lee FFY, Hedin BR, D’Alessandro A, Leach SM, and Alper S. Inflammation-induced alternative pre-mRNA splicing in mouse alveolar macrophages. G3. 10(2):555-567. (2020).