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Aerify3: A Potential New Treatment for Airway Inflammation in COPD

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Trial Objectives


Treatments for chronic obstructive pulmonary disease (COPD) may still leave people experiencing wheezing, coughing, or shortness of breath. Researchers in the Aerify3 study are investigating a medication called itepekimab, which has shown some potential in earlier clinical trials to improve symptoms in those with COPD.

COPD symptoms can be worsened by inflammation in the lungs that makes it harder to breathe. Itepekimab has been shown to reduce inflammation in the body without suppressing the immune system. This trial is investigating changes in gene expression in those treated with this drug to evaluate how their lung inflammation has been reduced.

Participants will undergo two bronchoscopies within the first 12 weeks of the study, and biopsies will be taken to study gene expression during the procedures. They also will be monitored for changes of symptoms and receive blood tests to monitor
changes in the blood cells.

Who Can Participate


Adults age 40-70 who are former smokers diagnosed with COPD, are experiencing chronic bronchitis and are willing to undergo bronchoscopy.

Age: 40-70 Gender: Any

Estimated Time Commitment


Approximately 9 clinic visits and 1 telephone visit, once every two weeks. Visits will take 1-4 hours

Payment & Reimbursement


Payment: Provided

Travel Reimbursement: Available

Trial Contact


For more information, contact:

Jennifer Underwood
303.398.1518

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Trial Location


National Jewish Main Campus, Denver, CO

Trial Sponsors


Sanofi

Principal Investigators

Steven E. Lommatzsch

Steven E. Lommatzsch, MD

Co-Investigators

Ann Granchelli

Ann Granchelli, MD

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